The new building on the northern side of the mall facing Murray Tce opened on Thursday afternoon.
Central Otago District Council community service manager Anne Pullar said a key feature of the new i-Site was a series of digital screen displays and interpretative wall panels promoting the region.
She encouraged people from the area to ''come in and have a look''.
''We hope it will make them feel proud of their town and region and the way we are showcasing it to visitors.''
The i-Site has, until now, shared a building with the Cromwell and Districts Museum, which will remain in the old building, operated by volunteers.
Opening the new facility brings an end to a nine-year process to establish a new i-Site in Cromwell.
Helen Scoles will manage staff at the facility, which will be open from 9am-7pm daily.