In the front row, Edinburgh Rugby trio Alasdair Dickinson, Ross Ford and Willem Nel start the match after their impressive replacement appearances last week, with John Barclay, David Denton and Ryan Wilson offering an impressive back row.
Glasgow Warriors Peter Horne starts alongside club mate Mark Bennett in midfield, while Finn Russell and captain Greig Laidlaw fill the halfback slots.
"It's a good indication of our growing quality and depth that we're able to pitch another quite different, yet talented, side into battle this Saturday," Cotter said.
"Many of these players have worked hard all summer long and have had to wait patiently on the sidelines for this opportunity."
Scotland team:
15-Stuart Hogg, 14-Sean Lamont, 13-Mark Bennett, 12-Peter Horne, 11-Tim Visser, 10-Finn Russell, 9-Greig Laidlaw (captain); 8-David Denton, 7-John Barclay, 6-Ryan Wilson, 5-Jonny Gray, 4-Grant Gilchrist, 3-Willem Nel, 2-Ross Ford, 1- Alasdair Dickinson.
Replacements: 16-Stuart McInally, 17-Gordon Reid, 18-Jon Welsh, 19-Robert Harley, 20-Blair Cowan, 21-Henry Pyrgos, 22-Ruaridh Jackson, 23-Matt Scott.
