Warburton, who sat out last week's victory over Ireland in Dublin with a shoulder injury, is back at openside flanker alongside James King and No 8 Taulupe Faletau.
Jake Ball and Dominic Day start in the second row, with the front row of Gethin Jenkins, Ken Owens and Tomas Francis unchanged from Dublin.
Halfbacks Rhys Webb and Dan Biggar continue their partnership while there is a new look midfield with Scott Williams lining up alongside Cory Allen.
The back-three from Dublin also remains unchanged with George North and Alex Cuthbert on the wings and Leigh Halfpenny at fullback.
"With our opening Rugby World Cup fixture just two weeks away, this weekend is an important run-out and an opportunity for fine tuning, said Gatland.
"We were happy with the performance away from home in Ireland last weekend, but there are plenty of things we need to work on from that victory so we will be looking to put those in place on Saturday.
"We've made a couple of changes to try a few new combinations and ensure players get some more game time under their belts."
Wales kick off their World Cup campaign against Uruguay in Cardiff on September 21.
Wales team:
15-Leigh Halfpenny, 14-Alex Cuthbert, 13-Cory Allen, 12-Scott Williams, 11-George North, 10-Dan Biggar, 9-Rhys Webb; 8-Taulupe Faletau, 7-Sam Warburton (captain), 6-James King, 5-Dominic Day, 4-Jake Ball, 3-Tomas Francis, 2-Ken Owens, 1-Gethin Jenkins.
Replacements: 16-Kristian Dacey, 17-Paul James, 18-Aaron Jarvis, 19-Luke Charteris, 20-Ross Moriarty, 21-Gareth Davies, 22-Rhys Priestland, 23-Matthew Morgan.
