The Highlanders will be travelling to South Africa for the semifinals following the Lions' defeat of the Crusaders in Johannesburg this morning.
Jamie Joseph's men have in recent weeks gone from South Africa to Argentina to New Zealand to Australia, where they beat the Brumbies 15-9 on Friday night.
But heading back to the Republic, they will be determined beat the Lions and defend their title, potentially setting up a replay of last year's decider against the Hurricanes.
The Highlanders dispatched the Lions 34-15 in March, but that result came with the benefit of home advantage.
This time they will be on the road, continuing an arduous travel schedule that could eventually catch up to them.
In the other semifinal, the top-qualifying Hurricanes will next weekend host the Chiefs in Wellington.
Dave Rennie's team will face a Hurricanes outfit in irrepressible form, following their win over the Crusaders with an equally comprehensive 41-0 shutout of the Sharks on Saturday night.
Chasing their first Super Rugby title, the Hurricanes will have to overturn the 28-27 defeat they suffered against the Chiefs at the Cake Tin in April, a memorable game that sets the stage for a mouthwatering knockout match.
If the Hurricanes can claim victory, the final will be in Wellington. If the Chiefs emerge triumphant, they will be playing away in the competition showpiece.
And the team standing in the opposite corner will be determined on Sunday morning at Ellis Park.
It all makes for a highly-anticipated weekend of rugby, one that could very easily culminate with an all-Kiwi final.
Super Rugby semifinals
Hurricanes v Chiefs (Wellington)
Lions v Highlanders (Johannesburg)
