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Gordon Mclean(63), also known as 'Gordy', has been missing since 3pm yesterday after leaving Wakari Hospital.
Police have issued a new picture of Gordy as they call for public assistance to find the man, whom they are "seriously concerned" about.
Sergeant Richard Panting, the search and rescue coordinator for coastal Otago police, said searchers, including two search and rescue dogs, had covered a large area already without luck.
They were now going door to door in the Wakari, Halfway Bush, Taieri Rd and Kaikorai areas seeking permission to search properties, and encouraged residents in those areas to also search their properties, under houses, in back yards and sheds, for Mr Mclean.
"We want to make sure he has not got himself stuck on someone's property."
He was described as approximately 152cm tall, of very thin build, and considered frail.
He was last seen wearing a dark-coloured polar fleece and trousers, and a red-coloured polo shirt.
He had brown slippers on and a black puffer sleeveless jacket.
Police were also concerned he may have fallen.
Any sightings of him should be reported to police immediately, Sgt Panting said