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The world will watch as 78-year-old Mr Biden takes power, his inauguration signalling the end of a turbulent four-year Donald Trump presidency.
Mr Biden’s running mate, Kamala Harris, will be sworn in as vice-president, becoming the first woman to assume the office. Her appointment will be a celebration in other ways, too, as a black woman also of South Asian descent.
For the first time in more than a century, the outgoing president will not attend his replacement’s inauguration, as Mr Trump is snubbing the ceremony.
An unprecedented security clampdown is planned in the aftermath of the January 6 Capitol invasion with thousands of police, Secret Service agents and members of the National Guard scrambled to Washington.
The traditional parade, luncheon and ball have been cancelled, replaced by a virtual parade with acts from around the US and a national TV special hosted by Tom Hanks.
But the ceremony still has some star power. Lady Gaga will sing the national anthem and Jennifer Lopez is also performing.