The Full House star is one of 11 parents hit with new charges.
Federal prosecutors in Boston said on Tuesday that Loughlin conspired to bribe University of Southern California employees to secure the admission of her two daughters.
Loughlin's husband, designer Mossimo Giannulli, has also been charged. Both maintain their innocence.
William "Rick" Singer, the consultant, pleaded guilty in March this year to charges that he facilitated cheating on college entrance exams and helped bribe sports coaches at universities to present his clients’ children as fake athletic recruits.
Earlier this month, Desperate Housewives star Felicity Huffman reported to prison after she admitted to engaging in the college exam cheating scheme and was sentenced to a 14-day term.