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The shootings occurred at the Jewish Community Center of Greater Kansas City in Overland Park, Kansas, and at Village Shalom, an assisted living centre about a mile away, according to local media.
Overland Park police said there were three confirmed fatalities and a person in custody.
Police did not immediately provide any further details.
A spokeswoman for Overland Park Regional Medical Center said the hospital was treating a 14-year-old male who suffered a gunshot wound and who was in critical condition.
Located in Kansas state, Overland Park is a suburb of Kansas City, Missouri.