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One person is believed to be critically injured after a truck collided with another vehicle south of Palmerston.
A police spokeswoman said they were called to the crash on State Highway 1 near Flag Swamp at 11.55am.
Initial indications were that one person had been critically injured. A helicopter was on the way from Dunedin.
The road was closed but has since reopened after the road was cleared.
The Serious Crash Unit would be advised.