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Five people have been left with injuries after a crash between a car and a truck north of Balclutha.
A police media spokeswoman said the crash happened about 10.20am.
One lane of State Highway 1 was blocked and police, fire and ambulance crews were on the scene.
One person had been trapped in a vehicle for a time.
St John spokesman Gerard Campbell said ambulance officers treated five people, two with moderate and three with minor injures.
The two people with moderate injuries were transported to Dunedin Hospital's emergency department, he said.
It was not known if the crash was caused by ice.