While tournament host Tiger Woods delivered the good, bad and ugly as he finished 14 shots back in his much anticipated return to competition, Matsuyama ended a dominant week with his worst round, a one-over 73 at the Albany course on the island of New Providence.
The 24-year-old Japanese, seven strokes ahead overnight in the elite 18-man event, birdied two of the first nine holes, then shrugged off a double at the 10th and a bogey at the 14th as he posted an 18-under total of 270 in blustery conditions.
British Open champion Henrik Stenson of Sweden eagled the par-five ninth on the way to a 68 and second place, with Americans Dustin Johnson (71), Rickie Fowler (69) and Matt Kuchar (70) a further three strokes back.
Woods, back in action after being sidelined for nearly 16 months due to back-related issues, endured a roller-coaster afternoon that included five birdies and three double-bogeys as he closed with a 76 for 15th place at four-under.
"I think it was a great week, to be back playing again and competing, playing against the best players in the world," Woods told Golf Channel. "Unfortunately I made a lot of mistakes this week, made a lot of birdies but a lot of mistakes.
"I made some poor decisions, missed the ball in the wrong spots and quite frankly it feels a little weird not to play in a cart," said Woods, who ran up a six at the par-four last after his tee shot ended up in an unplayable position in a bush.
"So it's a little different and I am getting used to that, getting my legs back and getting my body back, focusing for a long period of time. And these are all things that I have missed for about a year and a half."