Emergency services were called to Shaw Ave in New Brighton just before 6am today.
A Fire and Emergency spokesman says the single-storey house was well ablaze when they arrived.
He said they have three crews on the scene - and have managed to contain the fire.
Fire investigators are also at the scene, determining the cause of the blaze.
Cordons are currently in place.
A scene examination will be conducted and police and Fire and Emergency will investigate the circumstances.
Police said they were called to a boarding house fire at 5.45am.