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Emergency services attended a crash between a milk tanker and a car in Dunsandel on Sunday.
The crash at the intersection of Main South Rd (State Highway 1) and Parkins Rd was reported to police at 12.23pm.
A St John spokeswoman said one person had been taken by helicopter to Christchurch Hospital in a serious condition.
Fire and Emergency New Zealand (Fenz) sent crews from both Rakaia and Dunsandel to the crash.
The road was closed but is now open.