Strydom was a pharmacist by trade and played 21 tests between 1993 and 1997. He was 58.
He started the 1995 final where the home side defeated New Zealand 15-12 to take the crown in front of a beaming Nelson Mandela at Ellis Park.
"He was a hard-working lock who never shied away from getting stuck in and doing the dirty work," SA Rugby president Mark Alexander said in statement on Monday.
"To lose yet another member of the iconic Bok squad from 1995 is a heavy blow to the rugby fraternity here in South Africa."
Kitch Christie, who coached the team to their title win, died from cancer in 1998, as did flanker Ruben Kruger in 2010.
Scrumhalf Joost van der Westhuizen succumbed to motor neurone disease in 2017, and wings Chester Williams and James Small suffered fatal heart-attacks within two months of each other in 2019.
