The lawyers said in court papers filed in US district court in Massachusetts on Monday that the sworn interview should be delayed pending an appeal on whether Camille Cosby could be required to testify at all.
On December 31, a federal magistrate judge in Massachusetts rejected arguments by the comedian's wife of almost 52 years and Cosby's business manager, that the deposition would represent an "undue burden."
Cosby lawyers argued that the intimate nature of the questions expected during the deposition justified a delay, noting that their ability to object to such evidence at trial would not spare their client embarrassment.
"The Magistrate has suggested that the plaintiffs may ask Mrs. Cosby about the most intimate details of her marital life, including her husband's sexual 'proclivities,'" Camille Cosby's attorneys wrote.
"A trial objection will do Mrs. Cosby little good if the private and intimate details of her marital life are discussed during deposition and released to the media thereafter."
The ruling came a day after Cosby (78) was charged with sexually assaulting a woman who prosecutors say the comedian plied with drugs and alcohol in 2004, the only criminal case filed against the entertainer, whose reputation has been marred by dozens of similar misconduct accusations.
More than 50 women have come forward to accuse Cosby, best known for his role as Dr Cliff Huxtable in the 1980s television hit The Cosby Show of sexually assaulting them after plying them with drugs or alcohol.
Cosby has repeatedly denied wrongdoing and many of the allegations involve decades-old incidents and is free on $US1 million ($NZ1.4 million) bail. His lawyer has said the entertainer is not guilty and will not consider a plea bargain.
The Massachusetts civil lawsuit against Cosby was filed in December 2014 by Tamara Green, later joined by six other women, who contend that Cosby sexually assaulted or abused and then defamed them by calling each a liar, court documents said.
US Magistrate Judge David Hennessy also rejected arguments by Camille Cosby that she lacked any first-hand knowledge of the events at issue, and that the court should protect her from "unnecessary harassment" by limiting the scope of the subpoena.
