Runners will either run the whole access road, run the last 5.5km to the top or run the final 1km, and money raised through sponsorship will be donated to the Cancer Society.
Remarkables ski area manager Ross Lawrence said he hoped to complete the 5.5km to the top, and NZSki chief executive James Coddington would also be lacing his running shoes today.
Mr Lawrence said the 13km road rose from 350m to 1600m, "through 13km you actually climb quite a bit; that's 1300m in elevation".
Runners were encouraged to find sponsors to donate per kilometre.
Yesterday, four runners were confirmed to complete the full run, four had signed on to complete the 5.5km run, and three to run the home stretch, including NZSki mascots Spike and Shred.
Mr Lawrence said rentals department staff member Stefanie Gloeckner (pictured) instigated the inaugural run and NZSki had "decided to hop on board".
"It's all about the community as much as anything, [and] giving something back."
The access road would remain open to the public.
