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In what will only be her fifth special televised message to the country during her 68 years on the throne, Queen Elizabeth on Sunday will also thank healthcare workers on the front line and recognise the pain already suffered by some families in the address at 8pm on Sunday (local time).
"I hope in the years to come everyone will be able to take pride in how they responded to this challenge. And those who come after us will say that the Britons of this generation were as strong as any," the 93-year-old monarch will say, according to extracts released by Buckingham Palace.
"That the attributes of self-discipline, of quiet good-humoured resolve and of fellow-feeling still characterise this country."
On Saturday, the government said the death toll of those who had tested positive for the virus rose by 708 in 24 hours to 4313, with a 5-year-old among the dead, along with at least 40 who had no known previous health conditions.
Health officials have cautioned that high fatalities were expected for at least another week or two even if people complied with strict isolation measures.
Like many countries in Europe, Britain is in a state of virtual lockdown, with pubs, restaurants and nearly all shops closed, and social gatherings banned.
Britons have been told to stay at home unless it is absolutely essential to venture out to try to stop the spread of the epidemic. Prime Minister Boris Johnson, who is still in self-isolation, and a number of senior ministers have been among those who have tested positive for the virus.
'AS STRONG AS ANY'
"I am speaking to you at what I know is an increasingly challenging time," the Queen will say in what has been framed as a deeply personal message.
"A time of disruption in the life of our country: a disruption that has brought grief to some, financial difficulties to many, and enormous changes to the daily lives of us all."
Sunday's address was recorded at Windsor Castle where the monarch is staying with her 98-year-old husband Prince Philip.
In order to ensure any risk to the Queen herself was mitigated, it was filmed in a big room to ensure a safe distance between her and the cameraman, who was wearing personal protective equipment and was the only other person present.
Earlier this week, the Queen's son and heir Prince Charles (71) came out of self-isolation himself after seven days following a positive test.
The Queen usually only broadcasts to the nation with her annual televised Christmas Day message and this special address will be only the fifth she has made.
The last was in 2012 following celebrations to mark her 60th year as Queen. That came a decade after the preceding broadcast which followed the death of her mother, the Queen Mother, in 2002 when she thanked Britons for their messages of condolence.
She also gave an address at the start of the Gulf War in 1991, and most famously, delivered a sombre live broadcast after the death of her daughter-in-law Princess Diana in a Paris car crash in 1997 amid a national outpouring of grief and criticism of the royal family's response.