Emergency services were called to a head-on collision south of Edendale this morning.
Police, paramedics and firefighters were called to the crash in Salford St about 7.30am, a police spokesman said.
The crash blocked one lane for a short time, but the incident was described as minor.
Four people were involved in the crash, although none were seriously injured, a spokesperson said.
A man in his late teens and a woman in her 20s suffered minor-moderate injuries and were taken to Southland Hospital.
The road is now clear and traffic free flowing.
Inquiries were ongoing, the spokesman said.