Roads were closed to traffic in the area around the crash scene. Photo: Laura Smith
A police spokeswoman said the incident happened on the Winton-Lorneville Highway (SH6), about 4pm. The cause of the crash was not known.
Two people are in a critical condition, one is in a serious condition and one has had their injury status downgraded to minor.
It was earlier reported that one person was critically injured and three seriously hurt.
St John spokesman Gerard Campbell said all the victims were initially taken to Southland Hospital in Invercargill, but one of the critical patients had been sent to Dunedin Hospital.
Three ambulances, two helicopters and a manager attended.
SH6 remains closed, between Counsell Rd and Breeze Rd. A detour is in place. A Police spokeswoman said the Serious Crash Unit is on scene and the road will be closed overnight while their investigations take place.
