Angus Ta'avao comes into the front row for the injured Nepo Laulala, while teammate Mitchell Brown has recovered from concussion and will partner All Black Brodie Retallick at lock.
Brown's switch to the engine room allows Lachlan Boshier a chance to start at blindside flanker, with Liam Messam switching to No8.
Young gun Tiaan Falcon will again call the shots at five-eighth after a successful first Super Rugby game in his side's win over the Blues, meaning livewire Damian McKenzie will stay at fullback.
Several players might debut off the bench, with Jeff Thwaites covering tighthead prop.
Midfielder Bailyn Sullivan has also been bracketed with Marty McKenzie, who must pass a fitness test to be selected.
Scores of regulars - including Laulala, Dominic Bird, Tim Nanai-Williams, Charlie Ngatai, Shaun Stevenson, Atu Moli and Kane Hames - are unavailable.
Chiefs team to play the Bulls
Damian McKenzie, Sean Wainui, Anton Lienert-Brown, Johnny Fa'auli, Solomon Alaimalo, Tiaan Falcon, Brad Weber, Liam Messam, Sam Cane (c), Lachlan Boshier, Mitchell Brown, Brodie Retallick, Angus Ta'avao, Nathan Harris, Aidan Ross.
Reserves: Liam Polwart, Karl Tu'inukuafe, Jeff Thwaites, Michael Allardice, Luke Jacobson, Te Toiroa Tahuriorangi, Marty McKenzie or Bailyn Sullivan, Declan O'Donnell.