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Police said the freelance photographer, whose name has not officially been released, was killed by another driver on Tuesday evening (local time) after he crossed a busy highway to snap pictures of the Ferrari that had been stopped by police for speeding.
Bieber, 18, was not in the sports car, which was reportedly being driven by a friend.
"While I was not present nor directly involved with this tragic accident, my thoughts and prayers are with the family of the victim," the "Boyfriend" singer said in statement.
Bieber, who is followed day and night by photographers, said he hoped the incident "will finally inspire meaningful legislation and whatever other necessary steps to protect the lives and safety of celebrities, police officers, innocent public bystanders, and the photographers themselves."
Celebrity website TMZ.com said the photographer was following the Ferrari after seeing it pulling out of a Beverly Hills hotel on Tuesday evening, believing Bieber was inside the car.
Los Angeles police said the photographer was seen taking pictures of the traffic stop and was ordered by highway patrol officers to return to his car for safety reasons. He was struck by another motorist while trying to cross four lanes of traffic.
Bieber was stopped by police for speeding on a Los Angeles freeway last July, when the Canadian teen sensation told police he was being hounded by paparazzi.
But a Los Angeles judge in November threw out criminal charges against the photographer who was charged in that case under a new California law aimed at cracking down on aggressive photographers and celebrity media. Judge Thomas Robinson called the 2010 law "problematic" and "overly inclusive."
The death on Tuesday brought calls from some other celebrities for a halt to the sometimes 24/7 tracking of their activities at work, home and leisure.
Singer Miley Cyrus, 20, a frequent paparazzi target, sent out a stream of Twitter messages, referencing the death of Britain's Princess Diana in a 1997 car crash while being chased by paparazzi in Paris.
"Hope this paparazzi/JB accident brings on some changes in '13 Paparazzi are dangerous! Wasn't Princess Di enough of a wake up call?!" Cyrus tweeted.
"This was bound to happen! Your mom teaches u when your a child not to play in the street! The chaos that comes with the paparazzi acting like fools makes it impossible for anyone to make safe choices," Cyrus added.