From 12:01am on Saturday, Perth and the neighbouring Peel region will return to the conditions that existed prior to the Anzac Day weekend lockdown.
Face masks will only be required at the airport and there will no longer be limits on attendees at weddings and funerals.
Major venues including the 60,000-seat Optus Stadium will return to being able to host 100 percent capacity crowds.
Limits on home gatherings will also be removed and patients in hospitals, aged care and disability care facilities will be able to have unlimited visitors.
WA hasn't recorded any locally acquired cases since May 1 when a hotel security guard and his two housemates tested positive.
Perth and Peel have been subject to varying levels of restrictions for the past three weeks.
"Western Australians have done a fantastic job at crushing the virus in our community," Premier Mark McGowan said on Thursday.
"The return to pre-lockdown life is only possible because of the collective efforts of Western Australians."
A legal requirement for hotel quarantine workers to be vaccinated against COVID-19 came into effect on Monday.
The state is monitoring 13 active cases in hotel quarantine.
Mr McGowan said there were eight active cases of the Indian strain of the virus which is now being classified as a variant of concern.
"As more strains and variants are detected, it clearly highlights we're certainly not out of the woods with this pandemic," he said.
