The Winton man joins about 10,000 other New Zealanders who die from cancer each year.
Almost a year ago, Mr Vining was diagnosed with stage four bowel cancer and told he had eight weeks to live - the family decided to seek treatment privately after learning of the six to eight-week wait to begin treatment at Southland Hospital.
Faced with leaving behind his family, the 39-year-old made a bucket list that aimed to reduce the number of patients whose families would suffer the same.
His Facebook page, Blair Vining's Epic Journey, was used as a platform to generate nationwide conversation about under-resourced DHBs, and at 12.40pm, a post informed of his death.
"Blair's wife Melissa and their two daughters, Della-May and Lilly, will miss him immensely. They are exceptionally proud the man they will continue to love forever left the world a better place ... Details regarding an opportunity for the public to take part in a memorial service will be released at a later time."
More than 140,700 people signed the petition that called for better cancer care in New Zealand, as well as the creation of a national cancer agency.
Being the last item on his bucket list, it was presented to Parliament in July.
Parliament then announced its New Zealand Cancer Action Plan 2019-2029, which focused on delivering outcomes in four areas - consistent and modern cancer care, equitable cancer outcomes, fewer cancers and better cancer survival.
Health Minister David Clark expressed his condolences.
"Blair made a difference. I have huge respect for the selfless work he, and Melissa, put in advocating for better cancer care in New Zealand."
The Vining family recently began pushing for a Southland charity hospital.
Invercargill City Mayor Sir Tim Shadbolt posted on social media, "Selfless to the end. Today, as a region, we are in mourning. Let's ensure the charity hospital is established, in your honour. RIP Blair. My thoughts are with Missy and the girls."
