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The work of 22 Otago researchers, in areas ranging from diabetes and stroke to foetal alcohol spectrum disorder, has been recognised by career development awards from the Health Research Council (HRC).
Three scientists received prestigious, four-year Sir Charles Hercus Health Research Fellowships, amounting to $1.7 million.
In total, Otago University received $2.3million for general career development awards, $197,600 for Maori Health Career Development Awards and $196,980 for Pacific Health Career Development Awards.
Nationally, the HRC distributed $13.3million.
Otago scientist Dr Sunali Mehta gained a $600,000 Sir Charles Hercus Fellowship for research focusing on "Adapting to the CINister genome".
Cancer was a major health burden, accounting for one in three deaths in New Zealand, Dr Mehta said. Such deaths mainly resulted from spread of the disease (metastasis) and resistance to treatment, Dr Mehta said.
These disease features resulted from tumour evolution, which was driven by continuous changes in the DNA, called chromosomal instability (CIN).
"This study will enable us to identify individuals whose tumours have acquired the ability to evolve and are more likely to have a poor outcome, while providing information on novel ways of targeting pathways that promote CIN in tumours."
Dr Elodie Desroziers has received a $506,917 Sir Charles Hercus Fellowship to study the role of glial cells in fertility regulation.
Polycystic ovary syndrome was the most common infertility disorder, affecting 1 in 10 women of reproductive age in New Zealand and worldwide, Dr Desroziers said.
She would investigate the role of the brain in this disorder, and specifically the role of glial cells in the brain, which outnumbered neurons by 10 to one.
Other Otago funding: Clinical Research Training Fellowships, Dr Mercedes Burnside ($180,000), Sarah Goldsbury ($260,000), both Christchurch campus; Dr Ngaire Keenan, Wellington ($173,333); Maori Health Career Development Awards, Maori Health PhD Scholarship, Jordon Lima ($141,000); Maori Health Master’s Scholarship, Witana Petley ($31,600); Maori Health Summer Studentships ($5000): Brooke Bridges, Wellington; Raiha Cook, Wellington; Sade Gilbert-Perenise, Wellington; Jordon Lima; Saskia van der Wilt; Pacific Health Career Development Awards, Pacific Health Knowledge Translation Grant ($5000): Dr Losa Moata'ane, Jaye Moors, Troy Ruhe; Pacific Health PhD Scholarship, Jordan Taylor ($129,550); Pacific Health Master’s Scholarship, Oka Sanerivi ($32,430); Pacific Health Summer Studentships ($5000): Duncan Drysdale, Paige Enoka, Ileana Lameta, Urata Sofai.