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State Highway 1 is under stop-go traffic management after a vehicle towing a caravan crashed just south of Palmerston.
Police said emergency services were called to the scene of the crash, near the intersection with Patterson Rd, at about 2.40pm.
There are no reports of injuries.
The stretch of road is under stop/go traffic management with a temporary speed restriction in place.
It is the latest in a busy afternoon for emergency services in the South, after crashes near Omarama and Wānaka this afternoon.