The walk around Clyde begins at 6pm and is one of the activities in the week-long Alexandra Thyme Festival.
Organised by Promote Dunstan, the tour will take about an hour and include the historic facts about the landmark buildings, as well as adding "colour" with anecdotes from descendants of some of the buildings' former residents.
"That should add a special flavour to the tour," Promote Dunstan secretary Louise Joyce said.
Rosie Turnbull will be talking about her great-grandfather Henry Wong Gye, the Chinese police interpreter on the goldfields.
The cottage he lived in will be included in the tour and she will also talk about another historic home in Clyde's main street, where she lived as a child.
Sydney Mulligan, whose grandfather, Harold Stevens, took over the Dunstan Times in 1900, will talk about her family's link with one of the historic buildings.
The masonic lodge building will also be open, with lodge members on hand to show people around.
The tour will start at the miners' monument at the Clyde dam end of the main street.
