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Eastern Southland area response manager Senior Sergeant Cynthia Fairley said the pre-planned warrants were in relation to ongoing investigations.
"Staff were supported by PST (Public Safety Team), CIB (Criminal Investigation Branch) and Armed Offenders Squads from Invercargill and Dunedin," she said.
A police spokeswoman confirmed no arrests had been made, but the exercise was to "give reassurances and messaging" for the community.
"Police would like to reassure the Gore and Mataura townships that Police are proactive in the area and have increased patrolling," Sgt Fairley said.
"Police are committed to investigating drug offending and holding those responsible for supplying and dealing drugs, to account."
Anyone with information was urged to contact police.