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One person has been flown to Southland Hospital with serious injuries after a car and truck collided in Mataura's main street.
A police spokeswoman said they were called to the crash at 1.05pm today in Main St on State Highway 1, near the intersection with Dacre St.
Police said a helicopter was sent to the scene.
St John spokesman Gerard Campbell said one patient with serious injuries had to be flown to Southland Hospital in Invercargill.
Two other patients were treated at the scene.
Police said one had moderate injuries, the other had minor injuries.
Main St was reopened by 4.30pm.