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Emergency services were alerted to the incident in Rothesay Place, a residential street in the suburb of Rockdale, just before 1.30pm today.
A Fire and Emergency New Zealand spokesman said firefighters were called to the scene after being informed by ambulance.
Two crews were sent to the house, where they had to put out a fire in the kitchen, he said.
"Two firefighters extinguished the fire in breathing apparatus," he said.
The spokesman said the fire was being investigated.
A St John spokesman said two people with serious injuries were taken to Southland Hospital.
Another patient was treated at the scene for minor injuries.