Since Venus's first of five Wimbledon triumphs in 2000, the American siblings have won eight of the past 10 women's singles titles at the All England Club.
It is a remarkable run and, ominously for their rivals, the only change since Serena accounted for Venus last year in the fourth all-Williams final is the sisters being back at one and two in the world rankings for the first time since 2003.
"It's amazing. We work really hard, Venus works even harder than I do," Serena says.
"We really fight and do the best we can to be the best that we can be. That's what we play for and we both want to be No.1."
Their challengers look thin on the ground, especially on grass, a rarely-used surface these days, unfamiliar to most and where the Williams duo get added value for their awesome power games.
Former world No.1s Justine Henin, Kim Clijsters and Maria Sharapova loom as the most likely threats, while the vastly-improved Samantha Stosur could also feature at the business end of the tournament if she can maintain her magnificent form of 2010.
Henin, who reached this year's Australian Open final as a wildcard, returns for the first time since 2006 desperate to complete her grand slam set with victory at the All England Club.
"I will try to have fun in Wimbledon," the Belgian said.
"I don't want to compare my two careers, because it's so different.
"Everyone wants to see me at the level that I was and to compete. But the confidence I got in 2007, it took many years to be at that level."
Clijsters, also back at tennis's biggest event for the first time since 2006, had been sidelined since April with a foot injury but looked in scorching form in her comeback event this week at Eastbourne.
"I'm playing good tennis right now. I want to keep this level going for a little longer," Clijsters said.
Sharapova, who won Wimbledon as a 17-year-old back in 2004, is a shadow of the player she once was but zoomed back into focus with a charge to the final in Birmingham last week.
Stosur ousted Henin and Serena Williams en route to the French Open final on clay earlier this month, but the 26-year-old has less expectations heading for the London lawns, where she has traditionally struggled.
"To get past the third round would be nice," Stosur said.
"I've never been able to do that at Wimbledon, so I guess that's kind of goal No.1."
The Australian will be seeded sixth, giving her every chance of achieving her modest goal.
