After all, this is the same address where the climactic final events of one of last year's best video games, Fallout 3, took place.
That's right, a digitised version of Washington is getting blown up on television screens again, this time in a Wii-only video game called The Conduit, a new title that lets players blast away in locales around Washington, DC, such as the White House, Union Station and Reagan National Airport.
"There are so few games set in Washington, DC, and there's such great architecture there," said Eric Nofsinger, chief creative officer at the Chicago company that developed this new title.
"We quickly fell in love with it as a game space."
High Voltage Software isn't exactly a household name among gamers because the small outfit has specialised in taking some of the industry's less glamorous opportunities.
Case in point: Nofsinger and his colleagues decided to set their game in Washington after travelling there to meet government clients when developing a firefighter training simulator.
During those business trips, the team started to picture the city as a good backdrop for the action game that it hopes will put them on the map.
Aside from the setting, gamers have been chattering about The Conduit all year.
The popular Wii has introduced millions of mainstream consumers to the idea that they might like the occasional video game, but some gamers have turned their noses up at the console and its motion-sensing controllers, which they deride as a gimmick.
The Xbox 360 and the PlayStation 3 have more computer horsepower, and better graphics, after all.
The Conduit marks a somewhat rare attempt to make a Halo-style action game exclusively for Nintendo's console.
Playing on the Wii's unique strengths, The Conduit's controls were designed to be intuitive.
To toss a grenade, you flick your wrist in a throwing motion.
Run out of ammunition and you can make a quick jabbing motion to strike a bad guy in the face.
When your character's health is low, the controller throbs like a heartbeat.
Actor Mark Sheppard stars in The Conduit as the voice of the game's protagonist, government agent Michael Ford.
If you're a TV junkie, you're already familiar with Sheppard, who has appeared in Monk, CSI and 24.
Sci-fi fans might know Sheppard best as the twisted attorney on the recently concluded Battlestar Galactica.
Sheppard is a big fan of action games such as Call of Duty.
But even though he owns all the latest game consoles, the Wii at his house mostly had been gathering dust until now.
"I thought it was the most idiotic thing I'd ever heard of in my life," he said of his initial reaction to the project.
"Why would you make a first-person shooter for the Wii?"
So far, critics have also been favourable to High Voltage's attempt to break into the limelight.
The Conduit has gotten positive write-ups at Metacritic.com and influential game site IGN.com.
One piece of advice that I've recently gleaned from a few hours of playing The Conduit: If you ever get into a firefight with a spooky set of secret agents while speeding away from Reagan National on a mostly empty Metro train, be careful with your grenade lobbing arm.
Get a little too excited, you see, and the hand grenades bounce off the ceiling and land at your feet.
