Heritage Expeditions general manager David Bowen confirmed the 30-day voyage would depart from Dunedin on January 12, 2011.
The city was chosen as more than 100 hundred years earlier, Scott's Terra Nova expedition departed from Dunedin on November 29, 1910.
At the time, the explorer wrote in his diary: "We advertised our start at 3pm, and at three minutes to that hour the Terra Nova pushed off from the jetty".
Beaten to the South Pole by Norwegian Roald Amundsen, Scott and four of his expedition members died on the return journey.
Mr Bowen said the trip aboard the former Russian polar research vessel The Spirit of Enderby had almost sold out.
One group, Cambridge University's Scott Polar Research Institute, had booked half of the 50 available berths, with elderly descendants of Scott and Ernest Shackleton also confirmed for the trip, he said.
While the majority of passengers were from the United Kingdom, people from New Zealand, Canada, the United States and Australia would also travel on the voyage.
On the eve of the voyage, a special centennial expedition dinner, featuring guest speakers and invited members, would be held.
Highlights of the trip include visits to the Ross Ice Shelf, Scott and Shackleton's hut, and to McMurdo Station and Scott Base.
The trip is expected to end in Bluff on February 10, 2011.
