Police confirmed the deaths of the baby and a 22-year-old man this morning.
A teenager remains in critical condition in Dunedin Hospital. Three other people sustained non-life-threatening injuries in the crash.
Yesterday, media were told two people were critically injured, one seriously and a fourth person received minor injuries in the crash, which happened on the Winton-Lorneville Highway (State Highway 6), about 4pm.
The crash occurred about 150m north of the Makarewa Bridge, and the road remained closed between Counsell and Breeze Rds this morning.
A resident who lives near the crash site said today she saw emergency services vehicles "flying past'' her property, followed by a strong smell.
The woman, who wished to remain anonymous, told the Otago Daily Times she could smell a strong scent of rubber.
"You could just smell it, it must have been from the tyres squealing on the tarseal.''
In the 20 years she had lived in the area, the road to Winton had got progressively busier.
There had not been any crashes she could think of at the same site, apart from one.
"It would've been about 25 years ago when [the incident involving] Trevor McLeay happened.''
In 1995, Invercargill man Trevor McLeay was charged following the deaths of three young women in a crash.
The woman said she sent her condolences to everyone involved.
He had not been briefed about the accident as he had been in a meeting all morning.
The road would remain closed until the Serious Crash Unit’s investigation was completed, she said.
Three ambulances, two helicopters and a manager attended the accident scene, along with Fire and Emergency New Zealand and police staff.
St John spokesman Gerard Campbell said all of the patients were taken to Southland Hospital in Invercargill, but one of the critical patients was later flown to Dunedin Hospital.
Police asked anyone with information to contact them.
