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A police spokeswoman said they were called to the scene, in the middle of the intersection between Crawford (State Highway 1) and Jetty Sts, just after 6.30am.
The drivers of the two cars involved were both taken to hospital.
The road was closed for a time after the crash, but diversions had been removed by 7.45am.
A St John spokeswoman said two people were taken to hospital with minor injuries.