The report says 2085 pills seized were destined for the resort, surpassing Auckland by 700 pills.
Its says internet-facilitated drug trafficking - including on the "dark web" - has "increased exponentially" throughout the world, and seizures at the international mail centre have more than doubled in the past five years.
Otago-Lakes Central CIB head Detective Senior Sergeant Malcolm Inglis said the report came as no surprise to him because MDMA was "the drug of choice" in the region.
Queenstown and Wanaka had many young, short-term residents who were a "ready market" for the drug, as well as a small fraction of visitors who came to the resort towns to party.
Police could only assume the drugs seized at the border were a fraction of those reaching the provinces, he said.
"We're well aware the dark web is commonly used to source these drugs. The amount of items coming across our border through the post is massive, and you'd have to say there's a high percentage still getting through."
But methamphetamine, or P, which mainly came into the area from Auckland, was of most concern to police because of the harm it caused the community.
The report says the top three items bought by New Zealanders online are cannabis seeds, MDMA and prescription medications.
Bought mainly from the Netherlands, the United Kingdom and Canada, the drugs arrive at the centre every day, in small amounts.
MDMA seizures have increased significantly, from 8.7kg in 2016 - split across 706 items of mail - to 13kg last year.
