The most dramatic of the big blasts was a rare walk-off homer from Saints batter Lachie Brenssell.
Ellis Park Gold had led Saints all game and held a 3-2 lead going into the bottom of the seventh inning.
Saints got a man on base and then Brenssell launched into his game-winning home run over the right-field fence.
Saints made it two from two with a 15-4 win in four innings over Dodgers.
A feature of Saints' performance on opening day was the return of the talented Michael Crowley, who batted .750 through the two wins.
Cardinals beat Ellis Park Maroon 6-5 after a tiebreaker inning.
Maroon held an early lead before Cardinals scored a flurry of runs in the sixth inning. Steve Wallis was walked, Simon Maole smashed a homer over the left-field fence, and Crete Whaanga cleared centre field.
It was 5-5 through seven innings, before Wallis struck out three Maroon batters at the top of the eighth. Whaanga then batted in the winning run.
The opening game of the season was a 33-run, 170-minute epic between Ellis Park Maroon and Dodgers.
Maroon, inspired by veterans Greg Hurley, Andrew Melville, Scott Kindley, Wayne Vial and Alex Arkis, won 23-12 on the mercy rule.
Kindley, Vial and Ryan Williams all smashed homers in Maroon's 16-hits-to-8 win.