Emergency services were called to the scene, at Hillgrove, near Moeraki, at 3pm, a police spokeswoman said.
Police initially reported that two people had been injured, but in an update around 9pm they confirmed a person had been killed.
An Otago Daily Times reporter at the scene this afternoon said it appeared a car had hit a power pole, close to the Kemp Rd and Horse Range Rd intersection.
The road was blocked for a time.
Two helicopters attended, as well as police, fire crews and St John.
Meanwhile, police in Dunedin were called after a car hit a power pole in Musselburgh Rise at 2.51pm.
An ambulance had been called but it was unclear if there were any injuries.