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A police spokesman said they were called to the crash just after the Mosgiel on-ramp at 7.55am.
Three vehicles were involved in the crash and that the eastbound lanes were partially blocked.
Traffic was backed up and diverted for a time after the crash.
St John and Fire and Emergency New Zealand were also at the scene.
Traffic was also building up along the motorway.
A St John spokesman said six people were assessed at the scene, but only one person, who suffered minor injuries, required transporting to Dunedin Hospital.