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Three people, two with serious injuries, have been transported to Dunedin Hospital after a crash in Allanton.
Sergeant Matt Lee, of Dunedin, said officers were called to the two-vehicle collision East Taieri-Allanton Rd (State Highway 1), about 6.50pm on Tuesday.
There were five occupants between the two vehicles.
The road was closed for a short time while the vehicles were towed from the scene and the road was cleaned up, Sgt Lee said.
A Fire and Emergency New Zealand spokesperson said one car ended up off the road after hitting the other.
Two crews were sent to the scene and no-one was trapped.
A Hato Hone St John spokesperson said they responded with two ambulances and a rapid response vehicle.
Three patients, one in a moderate and two in serious conditions, were assessed at the scene and transported to hospital.