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Ten people were injured when shots rang out in the famed French Quarter of New Orleans early on Sunday (local time), according to the city's Police Department.
Most of the victims were taken to area hospitals, including two in critical condition. One victim walked in to a local hospital, officials said.
None of the victims have been publicly identified.
Officials initially reported 10 victims, then raised the number to 11 before returning to 10. It's unclear where the discrepancy comes from.
"The shootings on Canal Street early this morning were an ugly disruption of an otherwise beautiful holiday weekend. We will do everything we can to wrap the victims and their families in our love and support, and to bring the criminals responsible to justice," New Orleans Mayor LaToya Cantrell said in a statement.
"The City of New Orleans will not allow incidents like this to derail the progress we have made, or to further disrupt our community."
Police are still investigating to determine a suspect and motive, the NOPD said in a statement.
One person has been detained, but his or her "possible involvement in this incident remains under investigation," police said.
NOPD Superintendent Shaun Ferguson told reporters that there was already increased police presence in the area, specifically Canal Street, for the annual Thanksgiving weekend Bayou Classic football game between the Grambling State Tigers and the Southern Jaguars.
"We had officers on that very block that actually thought that they were being fired upon and took a position to respond to this," he said at a press conference. "Unfortunately, there were so many people out here, we were unable to determine who was actually firing shots at the time."
No officers were injured in the shooting.
Ferguson said police were looking at security footage in the area as part of the NOPD investigation,
"To the victims -- you are in our thoughts and prayers, and we will work tirelessly to bring those behind this cowardly act to justice," Ferguson said in a statement. "That is a promise."
After the 2016 Bayou Classic game, a shooting on Bourbon Street left one dead and nine people, ranging from ages 20 to 37, injured.