Emergency services responded to reports of a crash on the Cromwell-Clyde Rd (State Highway 8) about 12.50pm.
A police spokesman said four vehicles were involved and local staff had reported that one had left the road and gone down a bank.
The road was partially blocked and expected to be cleared by about 3pm, he said.
A Hato Hone St John spokeswoman said two patients in minor condition were assessed at the scene.
A Fire and Emergency NZ spokeswoman said two crews from Clyde and Cromwell and additional support vehicles attended.
One crew and a support crew remained on scene, helping with traffic management.
A tow truck had been called.
An Otago Daily Times reporter at the scene earlier said traffic was at a stand-still, but commenters on social media reported that it had started moving by about 2.40pm.
