Emergency services have been called to a serious crash near Waihola.
Police were notified of the single vehicle crash on State Highway 1 about 2.40pm today.
A spokeswoman for Hato Hone St John said an ambulance and helicopter were present at the scene along with a St John manager.
One occupant of the vehicle was airlifted to Dunedin hospital in a serious condition and another was driven by ambulance to the hospital in a moderate condition.
The road is operating under stop/go traffic management and motorists were advised to expect delays.