Fifth seed Stan Wawrinka suffered a first-round exit in the biggest upset of day one at Wimbledon.
The 32-year-old Swiss, who was struggling with a knee injury, fell to Russia's Wimbledon debutant Daniil Medvedev 6-4 3-6 6-4 6-1 on Centre Court at the London tournament.
Britian's defending champion Andy Murray had opened proceedings on the main show court by shrugging off a sore hip to launch his campaign in style, beating Kazakhstan's Alexander Bublik 6-1 6-4 6-2.
Murray, the world number one, hit 29 winners to wrap up the match in one hour 44 minutes. He will meet German Dustin Brown in the next round.
French Open champion Rafael Nadal also raced to a straight sets win over Australia John Millman but 20th seed Nick Kyrgios failed to reach the second round after retiring with a hip injury.
The talented 22-year-old called for the physio but packed up after losing the first two sets to Frenchman Pierre-Hugues Herbert 6-3 6-4.
Seventh-seeded Croatian Marin Cilic was in fine form as he defeated German Philipp Kohlschreiber 6-4 6-2 6-3 in the opening round.
Frenchman Jo-Wilfried Tsonga beat British wildcard Cameron Norrie 6-3 6-2 6-2 to book a spot in the second round. Tsonga, a two-times Wimbledon semi-finalist, recorded 30 winners on his way to a comfortable victory in an hour and 22 minutes.
Australian Nick Kyrgios, the 20th seed and a former Wimbledon quarter-finalist, retired with a hip injury after going 6-3 6-4 down to Frenchman Pierre-Hugues Herbert.
The injury hampered Kyrgios' movement during the majority of the match as he committed 17 unforced errors. World number 70 Herbert reached the second round of Wimbledon for the third consecutive year.
Venus through, Erakovic out
In the women's draw, five-time Wimbledon champion Venus Williams came through a tricky first-round test against Belgian Elise Mertens, emerging with a 7-6(7) 6-4 victory.
Twice champion Petra Kvitova of the Czech repubic opened her title bid with a 6-3 6-4 win over Sweden's Johanna Larsson.
The World number 12 was playing only her eighth match this year, having recently recovered from serious injuries to her playing hand sustained during a knife attack at her home last December.
French Open finalist Simona Halep beat New Zealand's Marina Erakovic 6-4 6-1 to book a second round spot.The Romanian broke her opponent's serve five times during a match lasting an hour and 13 minutes.
Fourth seed Elina Svitolina produced a fine display to see off Ashleigh Barty 7-5 7-6(8) in the first round.
There was also plenty to cheer for the home crowd with British number on Johanna Konta avenging her French Open first round defeat with a 6-2 6-2 win over Hsieh Su-Wei of Taiwan.
Konta's compatriot Heather Watson also reached round two, beating Belgium's Maryna Zanevska 6-1 7-6(5).
