Protestors carried placards bearing the messages "Shoulder to shoulder with British Jews" and "Zero tolerance for antisemites." Others showed the faces of Israeli hostages held by Palestinian militant group Hamas.
Some people sang in Hebrew while others chanted "Bring them home" in reference to the hostages.
"I’m here to support my Jewish community and I think we must stand up for ourselves, otherwise if we won't stand for ourselves who will, you know?" Avraham El Hay, a student, said.
London's Metropolitan Police received reports of 554 antisemitic offences between Oct. 1 and Nov. 1, up from 44 a year earlier, a more than 10-fold increase. Reports of Islamophobic offences almost tripled to 220 in the same period.
"I want this march to achieve for people to understand there is no place for racism in this country," Kate Worth, a travel agent, said. "We are all equal. And it's absolutely unacceptable what is happening right now for Jewish people."
Police arrested a far-right activist, Tommy Robinson, at the start of Sunday's march after he refused to leave the area at the request of police officers.
Organisers of the demonstration had asked Robinson not to attend because of the distress his presence was likely to cause.
Police also arrested a man who they said was heard to make antisemitic comments.
Sunday's march took place a day after a latest demonstration in the British capital by pro-Palestinian protestors calling for a permanent ceasefire in the Gaza Strip.
Police estimated 45,000 people marched in the demonstration on Saturday while it said 50,000 took part in Sunday's protest.
The Campaign Against Antisemitism, which focuses on the concerns of Jewish people in Britain, said the gathering was the biggest of its kind since the so-called Battle of Cable Street in 1936 when British fascists clashed with opponents in an area of east London where many Jews lived at the time.