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A 31-year-old woman and two men, aged 34 and 38, face a range of charges including unlawful possession of firearms, and possession and supply of Class A drugs, after police executed search warrants in Balclutha-Milton area.
Senior Sergeant Stanley Leishman said the raids were the culmination of Operation Wick, targeting meth-dealing in South Otago.
The operation was carried out by Balclutha police and the Dunedin Organised Crime Squad, he said.
Three firearms were seized along with an unspecified quantity of drugs.
''The physical and social carnage that methamphetamine causes to our communities is unacceptable and we are committed to lessening that harm.
''Police can't eliminate methamphetamine alone. It takes the wider community's assistance to help combat the negative impact of this drug.''
Police urged anyone affected by methamphetamine addiction to seek help through the Alcohol and Drug Helpline on 0800 787 797, or free text 1737.
Those with information about the supply of illicit drugs were urged to contact police.