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A police spokeswoman said a truck and a utility vehicle collided shortly before 2.30pm.
Appliances were sent from Balclutha and Waiwera South, a Fire and Emergency New Zealand communications spokesman said.
Fenz services were not required to rescue anyone as nobody was trapped in either of the vehicles, the spokesman said.
A St John spokesman said two patients with moderate injuries were transported to Clutha Health First in Balclutha by ambulance.