Three calls were received about 8.50am after nearby residents noticed smoke billowing out of the unoccupied house.
Two Mataura fire crews responded to the blaze before calling in more support from Gore, a total of four crews working in turn to contain the blaze.
Traffic was diverted around the main street as firefighters continued working throughout the morning, eventually getting the fire under control about 11am, the Gore crew returning shortly after.
The Mataura crews remained at the scene until noon, and the fire investigation unit is looking into the cause of the fire.
The house sustained significant damage but Fire and Emergency Services communication centre shift manager Lyn Crosson said there was no mention of any occupants involved.
Ms Crosson said incidents like yesterday morning’s showed the need for smoke alarms and diligence in protecting and mitigating harm during fires.
