Karen George, of Manhattan, lives above Madonna in a building on Central Park.
She said in a lawsuit filed Friday against the building's co-op board that the Material Girl is using her apartment as a rehearsal studio, forcing neighbors to endure "blaring music, stomping and shaking walls," for up to three hours each day.
George complained about "unreasonably high-decibel, amplified music" and vibrations pouring through walls, ceilings and radiators.
The building's board says it has already threatened to evict Madonna.
Madonna's representatives didn't immediately respond to a request for comment.