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The manager of this year's sale, Rosina Scott-Fyfe (20), said the sale benefited everybody, with students getting a chance to sell their textbooks and a percentage of the money going to charity.
Importantly, buying textbooks from the sale was significantly cheaper than buying them new, Ms Scott-Fyfe said.
She said there was no reason the sale would not be running in another 80 years, but expected it to change over time.
''We had one person come in and sell his lab coat and it sold straight away, so maybe we will evolve to not just taking textbooks,'' she said.
The sale, held at All Saints' Hall, 786 Cumberland St, also runs next week from Monday to Thursday and is open from 10am to 5pm.