When the first of the 10 chimes ring out from the Town Hall clock, Greene will attempt to get in front of sisters Nicola and Fiona Hely before the top of the hill.
The runner who reaches the top first can control the race on the downhill stretch to the Regent Theatre.
If Greene is in front at that point she has the strength and endurance to stay in front up the final stretch to the finish of the 243m race.
Greene demonstrated her form by winning the women's 800m in 2min 8.75sec at the Cooks Classic in Palmerston North midweek.
Her coach Jim Baird is concentrating on developing her speed this year and the strength work she is doing with Andrew Keene at the New Zealand Academy of Sport is helping this.
Greene (17) finished third in last year's race but it will not be easy to step up to the tape first because Nicola Hely (24) won the event in 2007 and Fiona Hely in 2008.
They are genuine sprinters and have more basic speed than Greene but the hills around the Octagon mean strength is also needed.
Ben Jowsey (Hill City) will be attempting to continue his steady rise in the men's event after finishing third in 2009 and second last year.
His main opposition will come from clubmates John Gilmour and Robert Jopp and Blair Grant (Taieri).
The Time Buster starts and finishes outside the New Zealand Shop, the sponsor of the event.
Cory Innes (Taieri) was the first runner to complete the run inside the time it takes the chimes of the town hall clock to sound 10 times for 10am, when he broke the record with a time of 31.63sec in 2008.
The women's record of 35.01sec was run by Anna Smythe (Hill City) in 1998.
There are cash incentives for the runners on the 243m course, with the men's and women's winners receiving $300.
There is another $500 at stake for breaking the record and an extra $250 for any runner who beats the chimes.
Time Buster
The facts
Venue: Octagon.
First held: 1992.
Distance: 243m.
Field: Six men, six women.
Records: Cory Innes (men) 31.63sec (2008), Anna Smythe (women) 35.01sec (1998).
